First-pass extracted concept

dopamine receptors

Candidate: concept label1 source documents4 linked claims

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Aliases

D1, D2, D3, D4 and D5 dopamine GPCRs

Evidence Snippets

The variety of physiological functions controlled by dopamine in the brain and periphery is mediated by the D1, D2, D3, D4 and D5 dopamine GPCRs.

Evidence 1Source 1DOI PubMedprovenance

Supporting Sources

Source 1review2014British Journal of PharmacologyDOI PubMed

1 evidence snippet 4 linked claims Claim 1 Claim 2 Claim 3

Linked Claims

Claim 1application summarysupports2014Source 1DOI PubMed

Drugs acting on dopamine receptors are important tools for management of schizophrenia, bipolar disorder, depression, and Parkinson's disease.

Claim 2mechanism summarysupports2014Source 1DOI PubMed

Dopamine receptors signal through mechanisms beyond canonical cAMP-mediated pathways, including alternate G protein coupling and non-G protein mechanisms involving ion channels, receptor tyrosine kinases, and β-arrestins.

Claim 3method impact summarysupports2014Source 1DOI PubMed

New in vivo techniques have significantly advanced understanding of dopamine receptor physiological functions.

Claim 4scope summarysupports2014Source 1DOI PubMed

Dopamine receptor family members D1-D5 mediate diverse physiological functions in the brain and periphery.