First-pass extracted concept

dopamine system dysregulation in major depressive disorder

Candidate: concept label1 source documents3 linked claims

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Evidence Snippets

Anhedonia is considered a core feature of major depressive disorder, and the dopamine system plays a pivotal role in the hedonic deficits described in this disorder.

Evidence 1Source 1DOI PubMedprovenance

Supporting Sources

Source 1review2017The International Journal of NeuropsychopharmacologyDOI PubMed

1 evidence snippet 3 linked claims Claim 1 Claim 2 Claim 3

Linked Claims

Claim 1circuit regulation summarysupports2017Source 1DOI PubMed

Dopaminergic activity is regulated by multiple brain structures, including the ventral subiculum of the hippocampus and the basolateral amygdala.

Claim 2disease mechanism summarysupports2017Source 1DOI PubMed

Basic and clinical studies demonstrate deficits of the dopaminergic system in depression, and these deficits likely originate from dysregulation of regulatory afferent circuits.

Claim 3pathophysiology summarysupports2017Source 1DOI PubMed

Anhedonia is a core feature of major depressive disorder and the dopamine system plays a pivotal role in the associated hedonic deficits.