Together, our findings demonstrate that the dMHb is involved in exercise motivation and the regulation of hedonic state, and is part of an intrinsic reinforcement circuit.
First-pass extracted concept
dorsal medial habenula
Candidate: concept label1 source documents6 linked claims
Live refresh every 5sNext refresh in 5s
Aliases
dMHb
Evidence Snippets
Supporting Sources
Linked Claims
Optical silencing of dorsal medial habenula outputs is aversive.
Quoted textsource-backed
whereas optical silencing of dMHb outputs is aversive
Mice with dorsal medial habenula lesions show deficits in sucrose preference but not in the forced swim test.
Quoted textsource-backed
These mice also show deficits in sucrose preference, but not in the forced swim test
Developmental elimination of dorsal medial habenula neurons via tissue-specific Pou4f1 deletion impairs motivation-based locomotor behaviors in mice.
Quoted textsource-backed
Mice with dMHb lesions perform poorly in motivation-based locomotor behaviors, such as voluntary wheel running and the accelerating rotarod
Optical activation of dorsal medial habenula neurons supports intracranial self-stimulation, indicating that dMHb activity is intrinsically reinforcing.
Quoted textsource-backed
Optical activation of the dMHb in vivo supports intracranial self-stimulation, showing that dMHb activity is intrinsically reinforcing
Mice with dorsal medial habenula lesions show only minor gait and balance abnormalities and normal basal locomotion.
Quoted textsource-backed
but show only minor abnormalities in gait and balance and exhibit normal levels of basal locomotion
The dorsal medial habenula is involved in exercise motivation, regulation of hedonic state, and an intrinsic reinforcement circuit.
Quoted textsource-backed
Together, our findings demonstrate that the dMHb is involved in exercise motivation and the regulation of hedonic state, and is part of an intrinsic reinforcement circuit.