Back to first-pass browser

First-pass extracted concept

double-projecting ventral CA1 hippocampal neurons

Candidate: concept label1 source documents5 linked claims
Jump to explainersJump to evidenceJump to sourcesJump to claims
Live refresh every 5sNext refresh in 5s

Aliases

double-projecting vCA1 neurons, vCA1 neurons projecting to both the mPFC and amygdala

Extracted Explainers

What the tool is doing

This paper studies ventral CA1 neurons that project to both the medial prefrontal cortex and amygdala. Their activation is linked to contextual information processing and excitatory drive to both targets.

Source 1DOIPubMed

Resources required

The abstract indicates that identifying this population required dual retrograde viral tracing, c-Fos immunostaining, optogenetic manipulation, and electrophysiological experiments.

Source 1DOIPubMed

What problem it solves

It helps explain how contextual information from ventral hippocampus could be routed to both mPFC and amygdala during contextual fear conditioning.

Source 1DOIPubMed

What it does not solve

The abstract does not establish a named reusable engineered reagent or provide molecularly specific access to this population.

Source 1DOIPubMed

Alternatives

The abstract contrasts these neurons with vCA1 neurons projecting to either the mPFC or amygdala alone.

Source 1DOIPubMed

Evidence Snippets

a proportion of vCA1 neurons projected to both the mPFC and amygdala
Evidence 1Source 1DOIPubMedprovenance

Supporting Sources

Linked Claims

Claim 1activity associationsupports2017Source 1DOIPubMed

Double-projecting ventral CA1 neurons were recruited preferentially during context exposure.

Quoted textsource-backed
and were recruited preferentially during context exposure
Claim 2circuit activationsupports2017Source 1DOIPubMed

Activation of double-projecting ventral CA1 neurons induced action potential firing in medial prefrontal cortex neurons that project to the amygdala.

Quoted textsource-backed
The activation of double-projecting vCA1 neurons also induced action potential firings in the mPFC neurons that project to the amygdala
Claim 3mechanistic modelsupports2017Source 1DOIPubMed

Double-projecting ventral CA1 neurons could contribute to contextual fear responses by synchronizing medial prefrontal cortex and amygdala activity and efficiently conveying contextual information to the basal amygdala.

Quoted textsource-backed
double-projecting vCA1 neurons could induce synchronized neural activity in the mPFC and amygdala and convey contextual information efficiently to the basal amygdala for contextual fear conditioning
Claim 4projection patternsupports2017Source 1DOIPubMed

A proportion of ventral CA1 neurons project to both the medial prefrontal cortex and amygdala.

Quoted textsource-backed
we found that a proportion of vCA1 neurons projected to both the mPFC and amygdala
Claim 5synaptic connectivitysupports2017Source 1DOIPubMed

Optogenetic stimulation of axon collaterals of double-projecting ventral CA1 neurons induced monosynaptic excitatory responses in both the medial prefrontal cortex and basal amygdala.

Quoted textsource-backed
optogenetic stimulation of axon collaterals of double-projecting vCA1 neurons induced monosynaptic excitatory responses in both the mPFC and basal amygdala