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double-stranded RNA-triggered crosstalk between RNA silencing and IFN response

Candidate: concept label1 source documents4 linked claims
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Aliases

RNA silencing-IFN crosstalk

Evidence Snippets

In mammalian cells, both RNA silencing and the IFN response are induced by double-stranded RNAs (dsRNAs) in the cytoplasm... recent reports have shed light on crosstalk between the two pathways, which are mutually regulated by protein-protein interactions triggered by viral infection.
Evidence 1Source 1DOIPubMedprovenance

Supporting Sources

Linked Claims

Claim 1biological implicationsupports2020Source 1DOIPubMed

Crosstalk between RNA silencing and the interferon response may constitute a novel antiviral defense system regulated by microRNAs in mammalian cells.

Claim 2mechanistic summarysupports2020Source 1DOIPubMed

Both RNA silencing and the interferon response are induced by cytoplasmic double-stranded RNAs in mammalian cells.

Claim 3mechanistic summarysupports2020Source 1DOIPubMed

The crosstalk between RNA silencing and the interferon response is described as being mediated by protein-protein interactions triggered by viral infection.

Claim 4pathway crosstalksupports2020Source 1DOIPubMed

RNA silencing and the type-I interferon response in mammalian cells are not fully independent pathways but show crosstalk and mutual regulation.