First-pass extracted concept

dual-input CAR-Ts

Candidate: concept label1 source documents3 linked claims

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Aliases

dual-input CAR-T

Evidence Snippets

Using logic gates as a framework, we categorize the numerous approaches that leverage two inputs instead of one to achieve better cancer selectivity or efficacy in solid tumors with dual-input CAR-Ts or multi-specific TCEs.

Evidence 1Source 1DOI PubMedprovenance

Supporting Sources

Source 1primary paper2024MEDDOI PubMed

1 evidence snippet 3 linked claims Claim 1 Claim 2 Claim 3

Linked Claims

Claim 1challenge statementsupports2024Source 1DOI PubMed

Achieving efficacy with CAR-T cell and T cell engager therapies in solid tumors has been more challenging than in hematological malignancies, in large part because of on-target off-tumor toxicities and sub-optimal T cell anti-tumor cytotoxic functions.

Claim 2design principlesupports2024Source 1DOI PubMed

Logic-gated approaches that use two inputs instead of one are presented as a way to improve cancer selectivity or efficacy in solid tumors for dual-input CAR-Ts and multi-specific T cell engagers.

Claim 3modality comparisonsupports2024Source 1DOI PubMed

IF/THEN and NOT gate types are described as pertaining more specifically to CAR-T therapies, but they may also succeed by integrating CAR-T and T cell engager technologies.