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dynamic allosteric interactions within spatially organized transient clusters

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This new view describes cell signaling in terms of dynamic allosteric interactions within and among distinct, spatially organized transient clusters.
Evidence 1Source 1DOIPubMedprovenance

Supporting Sources

Linked Claims

Claim 1conceptual contrastsupports2013Source 1DOIPubMed

At relevant spatial scales, cell signaling should be viewed not primarily as diffusion-controlled molecular collisions but as transient allostery-driven cluster re-forming interactions.

Quoted textsource-backed
Overall, our premise is that at these scales, cell signaling should be thought of not primarily as a sequence of diffusion-controlled molecular collisions, but instead transient, allostery-driven cluster re-forming interactions.
Claim 2conceptual modelsupports2013Source 1DOIPubMed

Cell signaling can be described as dynamic allosteric interactions within and among distinct, spatially organized transient clusters.

Quoted textsource-backed
This new view describes cell signaling in terms of dynamic allosteric interactions within and among distinct, spatially organized transient clusters.
Claim 3conceptual modelsupports2013Source 1DOIPubMed

Multiscale spatial organization of the cell organizes signaling and coordinates cellular behavior.

Quoted textsource-backed
We suggest that this multiscale spatial cell organization also organizes signaling and coordinates cellular behavior.