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dynamin-mediated fission

Candidate: concept label1 source documents3 linked claims
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Evidence Snippets

Elevated PI4P drives the fission enzyme dynamin to close the pores of preexisting and exocytosis-generated Ω-profiles.
Evidence 1Source 1DOIPubMedprovenance

Supporting Sources

Linked Claims

Claim 1comparative mechanismsupports2025Source 1DOIPubMed

PI4P, rather than PI(4,5)P2, is the key lipid for dynamin-mediated fission in this system.

Claim 2mechanismsupports2025Source 1DOIPubMed

Elevated PI4P drives dynamin to close pores of preexisting and exocytosis-generated Ω-profiles, triggering endocytic fission.

Claim 3mechanistic scopesupports2025Source 1DOIPubMed

Pore closure of Ω-profiles is sufficient to generate slow, fast, ultrafast, overshoot, and bulk endocytosis, and kiss-and-run in secretory cells.