First-pass extracted concept

endothelial cell dysfunction

Candidate: concept label1 source documents4 linked claims

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Evidence Snippets

In this review, we trace the evolution of the concept of endothelial cell dysfunction... consider current approaches to the clinical assessment of endothelial cell dysfunction; and outline some promising new directions for its early detection and treatment.

Evidence 1Source 1DOI PubMedprovenance

Supporting Sources

Source 1review2016Circulation ResearchDOI PubMed

1 evidence snippet 4 linked claims Claim 1 Claim 2 Claim 3

Linked Claims

Claim 1clinical assessment existssupports2016Source 1DOI PubMed

The review states that there are current approaches to the clinical assessment of endothelial cell dysfunction and promising directions for early detection and treatment.

Claim 2disease stage rolesupports2016Source 1DOI PubMed

Cellular and molecular mechanisms of endothelial cell dysfunction have pivotal roles in atherosclerotic lesion initiation and progression.

Claim 3functional scopesupports2016Source 1DOI PubMed

Endothelial cell dysfunction includes nonadaptive alterations in functional phenotype affecting hemostasis and thrombosis, vascular tone and redox balance, and acute and chronic inflammatory reactions within the arterial wall.

Claim 4pathobiology rolesupports2016Source 1DOI PubMed

Endothelial cell dysfunction is an important contributor to the pathobiology of atherosclerotic cardiovascular disease.