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First-pass extracted concept

endothelial tip cells

Candidate: concept label1 source documents4 linked claims
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Aliases

tip cells

Evidence Snippets

specialized endothelial cells situated at the tips of the vascular sprouts
Evidence 1Source 1DOIPubMedprovenance

Supporting Sources

Linked Claims

Claim 1cell state specific responsesupports2003Source 1DOIPubMed

Endothelial tip cells respond to VEGF-A by guided migration, whereas proliferative responses to VEGF-A occur in sprout stalks.

Quoted textsource-backed
The tip cells respond to VEGF-A only by guided migration; the proliferative response to VEGF-A occurs in the sprout stalks.
Claim 2gradient vs concentration dependencesupports2003Source 1DOIPubMed

Tip cell migration depends on a VEGF-A gradient, whereas proliferation is regulated by VEGF-A concentration.

Quoted textsource-backed
Whereas tip cell migration depends on a gradient of VEGF-A, proliferation is regulated by its concentration.
Claim 3mechanismsupports2003Source 1DOIPubMed

VEGF-A controls angiogenic sprouting in the early postnatal retina by guiding filopodial extension from endothelial tip cells.

Quoted textsource-backed
We show here that VEGF-A controls angiogenic sprouting in the early postnatal retina by guiding filopodial extension from specialized endothelial cells situated at the tips of the vascular sprouts.
Claim 4patterning modelsupports2003Source 1DOIPubMed

Vessel patterning during retinal angiogenesis depends on the balance between VEGF-A gradient and concentration properties that regulate distinct endothelial cell responses.

Quoted textsource-backed
Thus, vessel patterning during retinal angiogenesis depends on the balance between two different qualities of the extracellular VEGF-A distribution, which regulate distinct cellular responses in defined populations of endothelial cells.