First-pass extracted concept

engram cell-to-engram cell connectivity

Candidate: concept label1 source documents3 linked claims

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Extracted Explainers

What the tool is doing

The abstract presents functional connectivity between engram cells as a retained feature that correlates with preserved memory information. It is also implicated as necessary for optogenetic recall when downstream connectivity is inactivated.

Source 1DOI PubMed

What problem it solves

It offers a candidate storage substrate that can persist even when natural retrieval is impaired.

Source 1DOI PubMed

What it does not solve

The abstract does not show that connectivity alone is sufficient for normal natural recall.

Source 1DOI PubMed

Evidence Snippets

This long-term retention of memory information correlates with equally persistent retention of functional engram cell-to-engram cell connectivity.

Evidence 1Source 1DOI PubMedprovenance

Supporting Sources

Source 1primary paper2017Proceedings of the National Academy of SciencesDOI PubMed

1 evidence snippet 3 linked claims Claim 1 Claim 2 Claim 3

Linked Claims

Claim 1correlationsupports2017Source 1DOI PubMed

Long-term retention of memory information under amnesia correlates with persistent retention of functional engram cell-to-engram cell connectivity.

Claim 2mechanistic hypothesis supportsupports2017Source 1DOI PubMed

The results support the hypothesis that memory is stored as the specific connectivity between engram cells.

Claim 3necessitysupports2017Source 1DOI PubMed

Inactivation of connectivity from engram cell ensembles to downstream counterparts, but not upstream ones, prevents optogenetic memory recall.