Intriguingly, a considerable number of studies demonstrated the potential modulatory role of statins on endothelial nitric oxide synthase (eNOS)... In light of this view-point, we suggest in this review that eNOS upregulation and activation, in part, could play a fundamental role in the cardiovascular defensive potential of statins.
First-pass extracted concept
eNOS targeting by statins
Candidate: concept label1 source documents5 linked claims
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Aliases
endothelial nitric oxide synthase modulation by statins, eNOS modulatory role of statins
Evidence Snippets
Supporting Sources
Linked Claims
The review states that vascular nitric oxide generation has beneficial anti-inflammatory, anti-platelet, and vasodilatory actions.
Quoted textsource-backed
vascular generation of nitric oxide has beneficial anti-inflammatory, anti-platelet and vasodilatory actions
The review states that statin-induced activation of eNOS is mediated through PI3K/Akt signaling.
Quoted textsource-backed
statin-induced activation of eNOS is mediated through activation of phosphotidylinositol-3-kinase (PI3K)/protein kinase B (PKB/Akt) signals
The review states that statin-induced eNOS upregulation is mediated by inhibition of isoprenoid synthesis and prevention of Rho isoprenylation.
Quoted textsource-backed
The upregulation of eNOS by statins is mediated through inhibition of synthesis of isoprenoids and subsequent prevention of isoprenylation of small GTPase Rho
The review states that statins enhance eNOS activation by reducing caveolin-1 expression in vascular endothelium.
Quoted textsource-backed
Additionally, statins enhance eNOS activation by abrogating caveolin-1 expression in vascular endothelium.
The review argues that statin-mediated upregulation and activation of eNOS may contribute in part to the cardiovascular protective effects of statins.
Quoted textsource-backed
In light of this view-point, we suggest in this review that eNOS upregulation and activation, in part, could play a fundamental role in the cardiovascular defensive potential of statins.