This review will restrict itself to epidermal pigmentation.
First-pass extracted concept
epidermal pigmentation
Candidate: concept label1 source documents4 linked claims
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Evidence Snippets
Supporting Sources
Linked Claims
Epidermal pigmentation is regulated by interactions among melanocytes, keratinocytes, and fibroblasts through secreted factors, receptors, and cell-cell contacts.
Quoted textsource-backed
Each melanocyte at the basal layer of the epidermis is functionally connected to underlying fibroblasts in the dermis and to keratinocytes in the overlying epidermis. Those three types of cells are highly interactive and communicate with each other via secreted factors and their receptors and via cell/cell contacts to regulate the function and phenotype of the skin.
Melanoblast origin, migration, distribution, and differentiation into melanocytes are important determinants of visible pigmentation phenotype.
Quoted textsource-backed
Melanocytes are derived from precursor cells (called melanoblasts) during embryological development, and melanoblasts destined for the skin originate from the neural crest. The accurate migration, distribution, and functioning of melanoblasts/melanocytes determine the visible phenotype
Visible pigmentation of skin, hair, and eyes depends primarily on melanocyte function in synthesizing and distributing melanin.
Quoted textsource-backed
Visible pigmentation of the skin, hair, and eyes depends primarily on the functions of melanocytes, a very minor population of cells that specialize in the synthesis and distribution of the pigmented biopolymer melanin.
Visible skin color depends not only on melanin within melanocytes but also on pigment distributed into more superficial epidermal layers.
Quoted textsource-backed
Thus it is not the melanin within melanocytes only, but in combination with the pigment in more superficial layers, that gives skin its characteristic color.