Epigenetic editing has emerged as a promising approach in the treatment of neurological and neuropsychiatric disorders
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epigenetic editing
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The review states that proof-of-concept studies show epigenetic editing can prevent gene expression and alter transcriptional networks of diseased cells in living organisms.
Quoted textsource-backed
We also examine proof-of-concept studies that demonstrate how to prevent gene expression and alter the transcriptional networks of diseased cells in living organisms.
Current challenges for epigenetic editing in neurological and neuropsychiatric disorders include off-target effects, delivery issues, inadequate understanding of long-term stability, and the need for reliable diagnostics.
Quoted textsource-backed
We identify current challenges, including off-target effects, delivery issues, inadequate understanding of long-term stability, and the need for reliable diagnostics
The review states that dysregulation of DNA methylation, histone remodeling, and context-dependent gene regulation is essential to Alzheimer's disease, Parkinson's disease, Huntington's disease, and major psychiatric disorders.
Quoted textsource-backed
We emphasize that the dysregulation of these processes is essential to diseases such as Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), and major psychiatric disorders.
Epigenetic editing is presented as a promising approach for treating neurological and neuropsychiatric disorders by enabling precise and enduring modification of disease-associated genes.
Quoted textsource-backed
Epigenetic editing has emerged as a promising approach in the treatment of neurological and neuropsychiatric disorders, enabling the precise and enduring modification of genes associated with these conditions.