Epigenome editing, using programmable DNA-targeting tools to rewrite epigenetic information, has emerged as a powerful therapeutic strategy that directly addresses this molecular pathology.
First-pass extracted concept
epigenome editing
Candidate: concept label1 source documents3 linked claims
Live refresh every 5sNext refresh in 5s
Evidence Snippets
Supporting Sources
Linked Claims
In preclinical models of Angelman and Prader-Willi syndromes, targeted rewriting of epigenetic marks successfully reactivated silenced alleles and rescued disease-relevant phenotypes.
Quoted textsource-backed
convincing preclinical data in models of Angelman (AS) and Prader-Willi syndromes (PWS), where the targeted rewriting of epigenetic marks has successfully reactivated silenced alleles and rescued disease-relevant phenotypes
Epigenome editing is presented as a therapeutic strategy that directly addresses the molecular pathology of genomic imprinting disorders by rewriting epigenetic information.
Quoted textsource-backed
Epigenome editing, using programmable DNA-targeting tools to rewrite epigenetic information, has emerged as a powerful therapeutic strategy that directly addresses this molecular pathology.
Long-term durability and off-target safety remain challenges for translating precision epigenetic therapy into medicines.
Quoted textsource-backed
the remaining challenges-including long-term durability and off-target safety-that must be overcome to translate this scientific potential into transformative medicines