First-pass extracted concept

epithelial-mesenchymal transition

Candidate: concept label2 source documents4 linked claims

Jump to evidence Jump to sources Jump to claims

Live refresh every 5sNext refresh in 5s

Aliases

EMT

Evidence Snippets

it is necessary to assess the influence of the tested compounds on cellular processes such as the cell cycle, epithelial-mesenchymal transition, autophagy, and apoptosis.

Evidence 1Source 1DOI PubMedprovenance

epithelial-mesenchymal transition (EMT)

Evidence 2Source 2DOI PubMedprovenance

Supporting Sources

Source 1primary paper2025MEDDOI PubMed

1 evidence snippet 1 linked claim Claim 1

Source 2primary paper2015OncotargetDOI PubMed

1 evidence snippet 3 linked claims Claim 1 Claim 2 Claim 3

Linked Claims

Claim 1assessment prioritysupports2025Source 1DOI PubMed

To develop effective anti-cancer therapy, the influence of tested compounds should be assessed on cell cycle, epithelial-mesenchymal transition, autophagy, and apoptosis.

Quoted textsource-backed

To develop effective anti-cancer therapy, it is essential to understand the processes regulating the progression and suppression of a given type of cancer. For this reason, it is necessary to assess the influence of the tested compounds on cellular processes such as the cell cycle, epithelial-mesenchymal transition, autophagy, and apoptosis.

Claim 2gain of functionsupports2015Source 2DOI PubMed

Vimentin overexpression in MCF7 cells increased cell stiffness, elevated cell motility and directional migration, reoriented microtubule polarity, and increased EMT phenotypes.

Claim 3mechanistic associationsupports2015Source 2DOI PubMed

The increased EMT phenotypes observed with vimentin overexpression in MCF7 cells were associated with increased β1-integrin and loss of E-cadherin.

Claim 4paper conclusionsupports2015Source 2DOI PubMed

Vimentin serves as a regulator that maintains intracellular mechanical homeostasis in EMT cancer cells by mediating cytoskeleton architecture and the balance of cell force generation.