First-pass extracted concept

Epstein-Barr virus-positive gastric adenocarcinoma subtype

Candidate: concept label1 source documents3 linked claims

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Aliases

EBV-positive tumours

Evidence Snippets

We propose a molecular classification dividing gastric cancer into four subtypes: tumours positive for Epstein-Barr virus...

Evidence 1Source 1DOI PubMedprovenance

Supporting Sources

Source 1primary paper2014NatureDOI PubMed

1 evidence snippet 3 linked claims Claim 1 Claim 2 Claim 3

Linked Claims

Claim 1clinical implicationsupports2014Source 1DOI PubMed

Identification of the four molecular subtypes provides a roadmap for patient stratification and trials of targeted therapies.

Claim 2molecular classificationsupports2014Source 1DOI PubMed

The study proposes a molecular classification of gastric cancer into four subtypes: Epstein-Barr virus-positive, microsatellite unstable, genomically stable, and chromosomal instability.

Claim 3subtype associationsupports2014Source 1DOI PubMed

Epstein-Barr virus-positive gastric tumours display recurrent PIK3CA mutations, extreme DNA hypermethylation, and amplification of JAK2, CD274 (PD-L1), and PDCD1LG2 (PD-L2).