First-pass extracted concept

equine metabolic syndrome

Candidate: concept label1 source documents5 linked claims
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Aliases

EMS

Evidence Snippets

“EMS” was adopted as the name for this condition because it has gained wide acceptance and is appropriate when used to define a clinical syndrome unique to equids.
Evidence 1Source 1DOIPubMedprovenance

Supporting Sources

Linked Claims

Claim 1associationmixed2010Source 1DOIPubMed

Obesity has been associated with reduced insulin sensitivity in horses and ponies, although some obese horses have normal insulin sensitivity.

Quoted textsource-backed
Obesity has been associated with reduced insulin sensitivity in horses and ponies, although some obese horses have normal insulin sensitivity.
Claim 2causal modelsupports2010Source 1DOIPubMed

Laminitis can be experimentally induced by infusing supraphysiological amounts of insulin intravenously over 2 to 3 days.

Quoted textsource-backed
the condition can be experimentally induced by infusing supraphysiological amounts of insulin IV over 2–3 days
Claim 3definitionsupports2010Source 1DOIPubMed

Equine metabolic syndrome is a clinical syndrome in equids whose principal phenotype includes increased adiposity, insulin resistance, and a predisposition toward laminitis.

Quoted textsource-backed
The panel proposed that the EMS phenotype for the majority of affected equids should include: Increased adiposity ... IR ... A predisposition toward laminitis.
Claim 4predictive thresholdsupports2010Source 1DOIPubMed

A neck circumference-to-height at withers ratio greater than 0.71 was used to predict development of pasture-associated laminitis in ponies.

Quoted textsource-backed
The neck circumference-to-height at withers ratio was recently used to predict the development of pasture-associated laminitis in ponies and a cut-off value of >0.71 was established.
Claim 5risk associationsupports2010Source 1DOIPubMed

Insulin resistance and/or hyperinsulinemia predispose ponies to pasture-associated laminitis.

Quoted textsource-backed
We are limited at present to the knowledge that IR and/or hyperinsulinemia predispose ponies to pasture-associated laminitis