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Esr1+ LHA-LHb neurons

Candidate: concept label1 source documents4 linked claims
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Aliases

Esr1+ LHA-LHb neural activity, Esr1+ LHA neurons that project to the lateral habenula

Evidence Snippets

Here, we define a striosomal Tac1+/Tshz1+/Oprm1+ neuron subtype in the nucleus accumbens (ACB) that targets Esr1+ LHA neurons that project to the lateral habenula (LHb).
Evidence 1Source 1DOIPubMedprovenance

Supporting Sources

Linked Claims

Claim 1behavioral effectsupports2025Source 1DOIPubMed

Activation of the D1+ ACB-LHA projection or inhibition of LHA-LHb neurons defined by ACB inputs can drive reward-independent compulsive-like behaviors that generalize across contexts.

Quoted textsource-backed
We found that either activation of the D1+ ACB-LHA projection or inhibition of LHA-LHb neurons defined by ACB inputs can drive reward-independent compulsive-like behaviors that generalize across contexts.
Claim 2causal circuit rolesupports2025Source 1DOIPubMed

A discrete Tac1+ striosomal ACB projection targeting the aversive Esr1+ LHA-LHb pathway promotes stereotyped and compulsive-like behaviors over goal-directed actions.

Quoted textsource-backed
Our findings reveal a discrete Tac1+ striosomal ACB projection targeting the aversive Esr1+ LHA-LHb pathway as a key circuit that promotes stereotyped and compulsive-like behaviors over goal-directed actions.
Claim 3circuit definitionsupports2025Source 1DOIPubMed

A striosomal Tac1+/Tshz1+/Oprm1+ neuron subtype in the nucleus accumbens targets Esr1+ LHA neurons that project to the lateral habenula.

Quoted textsource-backed
Here, we define a striosomal Tac1+/Tshz1+/Oprm1+ neuron subtype in the nucleus accumbens (ACB) that targets Esr1+ LHA neurons that project to the lateral habenula (LHb).
Claim 4functional effectsupports2025Source 1DOIPubMed

Intersectional cell type-specific and input-output defined optogenetic activation of the ACB-LHA-LHb pathway progressively induces a negative behavioral state that depends on Esr1+ LHA-LHb neural activity.

Quoted textsource-backed
Intersectional cell type-specific and input-output defined optogenetic activation of this ACB-LHA-LHb pathway can progressively induce a negative behavioral state that depends on Esr1+ LHA-LHb neural activity.