First-pass extracted concept

excitatory-inhibitory imbalance

Candidate: concept label2 source documents4 linked claims

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Aliases

E/I balance, E/I imbalance

Evidence Snippets

Neural excitatory/inhibitory (E/I) imbalance plays a pivotal role in the aging process.

Evidence 1Source 1DOI PubMedprovenance

underlying excitatory-inhibitory (E/I) imbalance, a common finding in ASD models

Evidence 2Source 2DOI PubMedprovenance

Supporting Sources

Source 1primary paper2025MEDDOI PubMed

1 evidence snippet 3 linked claims Claim 1 Claim 2 Claim 3

Source 2primary paper2025MEDDOI PubMed

1 evidence snippet 1 linked claim Claim 1

Linked Claims

Claim 1associationsupports2025Source 1DOI PubMed

The genes discussed in the review show an association with age-related motor neuron diseases such as ALS.

Claim 2disease mechanismsupports2025Source 1DOI PubMed

Disruptions in excitatory/inhibitory balance contribute to the pathophysiology of age-related motor dysfunction.

Claim 3mechanistic hypothesissupports2025Source 2DOI PubMed

The review proposes that core ASD social and behavioral features may stem from somatosensory system dysfunction driven by excitatory-inhibitory imbalance.

Quoted textsource-backed

This review proposes that these core features may stem from somatosensory system dysfunction responsible for processing sensory information driven by an underlying excitatory-inhibitory (E/I) imbalance

Claim 4mechanistic rolesupports2025Source 1DOI PubMed

Neural excitatory/inhibitory imbalance plays a pivotal role in the aging process.