First-pass extracted concept

exosome-mediated tau aggregate transmission

Candidate: concept label1 source documents3 linked claims

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Aliases

transmission of tau aggregates by exosomes

Evidence Snippets

One vehicle for the transmission of tau aggregates are secretory nanovesicles known as exosomes.

Evidence 1Source 1DOI PubMedprovenance

Supporting Sources

Source 1primary paper2018Acta Neuropathologica CommunicationsDOI PubMed

1 evidence snippet 3 linked claims Claim 1 Claim 2 Claim 3

Linked Claims

Claim 1implicationsupports2018Source 1DOI PubMed

Fusion events involving endogenous endosomal secretory machinery may increase the pathogenic potential and radius of action of pathogenic cargoes carried by exogenous exosomes.

Claim 2mechanismsupports2018Source 1DOI PubMed

Exogenous exosomes isolated from rTg4510 mouse brains are internalized by recipient neurons and then passed on to another interconnected neuron.

Claim 3mechanismsupports2018Source 1DOI PubMed

Exosomes are a vehicle for transmission of tau aggregates between cells.