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F8 SARS-CoV-2 E gene variant

Candidate: concept label1 source documents3 linked claims
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Aliases

F8

Extracted Explainers

What the tool is doing

F8 is the SARS-CoV-2 variant studied here, defined in the abstract by a 12-bp deletion in the E gene and contrasted with the 8X wild-type comparator.

Source 1DOIPubMed

Evidence Snippets

We previously identified a SARS-CoV-2 variant (F8) containing a 12-bp deletion in the E gene.
Evidence 1Source 1DOIPubMedprovenance

Supporting Sources

Linked Claims

Claim 1differential expressionsupports2025Source 1DOIPubMed

In Calu-3 cells, infection with the SARS-CoV-2 F8 E-gene variant significantly downregulated let-7b-5p compared with the 8X strain.

Claim 2differential expressionsupports2025Source 1DOIPubMed

In Calu-3 cells, infection with the SARS-CoV-2 F8 E-gene variant significantly upregulated miR-361-3p compared with the 8X strain.

Claim 3pathogenesis mechanismsupports2025Source 1DOIPubMed

The SARS-CoV-2 E protein mutant F8 remodeled the host miRNA network to coordinate immune responses and barrier function in infected Calu-3 cells.