First-pass extracted concept

FAP-CAR-engineered Jurkat cells

Candidate: concept label1 source documents3 linked claims

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Aliases

engineered Jurkat cells

Evidence Snippets

we generated FAP-CAR-engineered Jurkat cells as a preliminary screening model

Evidence 1Source 1DOI PubMedprovenance

Supporting Sources

Source 1primary paper2025MEDDOI PubMed

1 evidence snippet 3 linked claims Claim 1 Claim 2 Claim 3

Linked Claims

Claim 1delivery approachsupports2025Source 1DOI PubMed

The study used lentiviral vectors and lipid nanoparticles to generate FAP-CAR-engineered Jurkat cells as a preliminary screening model.

Quoted textsource-backed

Using two delivery approaches-lentiviral vectors and lipid nanoparticles (LNPs)-we generated FAP-CAR-engineered Jurkat cells as a preliminary screening model

Claim 2functional activitysupports2025Source 1DOI PubMed

FAP-CAR-engineered Jurkat cells selectively recognized and induced apoptosis in FAP-expressing cardiac myofibroblasts.

Quoted textsource-backed

These engineered cells selectively recognized and induced apoptosis in FAP-expressing cardiac myofibroblasts

Claim 3safety signalsupports2025Source 1DOI PubMed

FAP-CAR-engineered Jurkat cells did not trigger excessive IL-6 secretion in the reported in vitro setting.

Quoted textsource-backed

without triggering excessive IL-6 secretion