We identified two distinct (fast and slow) types of ICWs at varying degrees of flow shear stress-induced membrane deformation, as determined by different bubble standoff distances.
First-pass extracted concept
fast intracellular calcium waves
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fast ICWs
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Intracellular calcium wave speed correlates strongly with the severity of cell injury, with fast waves traveling at 33 to 93 micrometers per second and slow waves traveling at 1.4 to 12 micrometers per second.
Quoted textsource-backed
The speed of ICW (CICW) was found to correlate strongly with the severity of cell injury, with CICW in the range of 33 μm/s to 93 μm/s for fast ICWs and 1.4 μm/s to 12 μm/s for slow ICWs.
Fast intracellular calcium waves are initiated by extracellular calcium influx primarily through poration sites near the jetting flow, whereas slow intracellular calcium waves are initiated by extracellular calcium influx through mechanosensitive ion channels, and both then propagate via a reaction-diffusion process from the endoplasmic reticulum.
Quoted textsource-backed
We showed that ICWs were initiated by an extracellular calcium influx across the cell membrane nearest to the jetting flow, either primarily through poration sites for fast ICWs or opening of mechanosensitive ion channels for slow ICWs, which then propagated in the cytosol via a reaction-diffusion process from the endoplasmic reticulum.
Two distinct intracellular calcium wave types, fast and slow, occur at varying degrees of flow shear stress-induced membrane deformation determined by different bubble standoff distances.
Quoted textsource-backed
We identified two distinct (fast and slow) types of ICWs at varying degrees of flow shear stress-induced membrane deformation, as determined by different bubble standoff distances.