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fat-related sensory cues

Candidate: concept label1 source documents5 linked claims
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Aliases

fat-related odours, non-nutritive sensory components of a high-fat diet

Evidence Snippets

Here, we show that non-nutritive sensory components of a high-fat diet (HFD), beyond its hypercaloric, obesogenic effects, are sufficient to alter metabolic health in the offspring.
Evidence 1Source 1DOIPubMedprovenance

Supporting Sources

Linked Claims

Claim 1causal effectsupports2025Source 1DOIPubMed

Non-nutritive sensory components of a high-fat diet are sufficient to alter metabolic health in offspring.

Quoted textsource-backed
Here, we show that non-nutritive sensory components of a high-fat diet (HFD), beyond its hypercaloric, obesogenic effects, are sufficient to alter metabolic health in the offspring.
Claim 2conceptual modelsupports2025Source 1DOIPubMed

Fat-related sensory cues during development can prime central responses to food cues and whole-body metabolism regulation.

Quoted textsource-backed
Collectively, we report that fat-related sensory cues during development act as signals that can prime central responses to food cues and whole-body metabolism regulation.
Claim 3mechanistic effectsupports2025Source 1DOIPubMed

Developmental exposure to fat-related odours shifts mesolimbic dopaminergic circuits and AgRP neuron responses to resemble those of obese mice, including desensitization of AgRP neurons to dietary fat.

Quoted textsource-backed
Developmental exposure to fat-related odours shifts mesolimbic dopaminergic circuits and Agouti-related peptide (AgRP) hunger neurons' responses to phenocopy those of obese mice, including a desensitization of AgRP neurons to dietary fat.
Claim 4negative resultsupports2025Source 1DOIPubMed

Neither neonatal optogenetic activation of sensory circuits alone nor passive exposure to fat-related odours alone is sufficient to alter metabolic responses to high-fat diet.

Quoted textsource-backed
While neither neonatal optogenetic activation of sensory circuits nor passive exposure to fat-related odours is sufficient to alter metabolic responses to HFD
Claim 5phenotype associationsupports2025Source 1DOIPubMed

Developmental exposure to fat-related odours causes offspring to display metabolic inflexibility and increased adiposity when fed a high-fat diet in adulthood independently of maternal metabolic health.

Quoted textsource-backed
Offspring exposed to these fat-related odours during development display metabolic inflexibility and increased adiposity when fed HFD in adulthood independently of maternal metabolic health.