Profound and debilitating fatigue is the most common complaint reported among individuals with autoimmune disease... This review describes how inflammation and the central nervous system contribute to fatigue and suggests potential mechanisms involved in fatigue that are likely exhibited in autoimmune and related diseases.
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fatigue in autoimmune and related disorders
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Inflammation affects physiological processes implicated in fatigue, including oxygen and nutrient supply, metabolism, mood, motivation, and sleepiness.
The central nervous system is described as an important contributor to fatigue in autoimmune and related disorders.
The exact mechanisms of fatigue are not well understood, in part because fatigue is broadly defined and manifests across diseases with diverse pathology.
The review states that profound and debilitating fatigue is the most common complaint reported among individuals with autoimmune disease.
The review focuses on how inflammation and the central nervous system contribute to fatigue and proposes potential mechanisms likely shared across autoimmune and related diseases.