First-pass extracted concept

fear extinction

Candidate: concept label2 source documents7 linked claims

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Evidence Snippets

Fear extinction is an evolutionarily conserved biological process

Here we examine emerging evidence that stress impairs recovery from trauma by impairing fear extinction, a form of learning thought to underlie the suppression of trauma-related fear memories.

Evidence 2Source 2DOI PubMedprovenance

Supporting Sources

Source 1primary paper2025MEDDOI PubMed

1 evidence snippet 4 linked claims Claim 1 Claim 2 Claim 3

Source 2review2015NeuropsychopharmacologyDOI PubMed

1 evidence snippet 3 linked claims Claim 1 Claim 2 Claim 3

Linked Claims

Claim 1causal perturbationsupports2025Source 1DOI PubMed

Inhibition of CA1 astrocytic Ca2+ dynamics impairs fear extinction, whereas activation of these dynamics facilitates fear extinction.

Quoted textsource-backed

Inhibition of these astrocytic Ca2+ dynamics impairs, while their activation facilitates, fear extinction.

Claim 2mechanistic rolesupports2025Source 1DOI PubMed

Hippocampal CA1 astrocytes exhibit de novo Ca2+ dynamics during fear extinction.

Quoted textsource-backed

Here, we show that hippocampal CA1 astrocytes exhibit de novo Ca2+ dynamics during fear extinction.

Claim 3pathway importancesupports2025Source 1DOI PubMed

A pathway from posterior basal forebrain cholinergic neurons to CA1 astrocytes governs natural fear extinction.

Quoted textsource-backed

our findings demonstrate a previously unrecognized and crucial pathway from pBF cholinergic neurons to CA1 astrocytes that governs natural fear extinction

Claim 4pharmacologic effectsupports2025Source 1DOI PubMed

Donepezil increases CA1 astrocytic Ca2+ dynamics and facilitates fear extinction.

Quoted textsource-backed

Clinically used acetylcholinesterase inhibitor donepezil increases CA1 astrocytic Ca2+ dynamics and facilitates fear extinction.

Claim 5mechanistic summarysupports2015Source 2DOI PubMed

Structural and functional abnormalities in the amygdala, prefrontal cortex, and hippocampus may underlie stress-induced impairments in fear extinction.

Claim 6review summarysupports2015Source 2DOI PubMed

Stress impairs recovery from trauma by impairing fear extinction.

Claim 7therapeutic hypothesis summarysupports2015Source 2DOI PubMed

Stress-induced neurochemical and molecular alterations associated with extinction deficits may be targetable to prevent or reverse impaired extinction.