The past several years have witnessed an increased presence of control theoretic concepts in synthetic biology. This review presents an organized summary of how these control design concepts have been applied to tackle a variety of problems faced when building synthetic biomolecular circuits in living cells.
First-pass extracted concept
feedback control in synthetic biology
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Control design methods can make synthetic genetic circuit behavior within single cells or across cell populations more reliable, predictable, and robust to perturbations.
Quoted textsource-backed
we describe success stories that demonstrate how simple or more elaborate control design methods can be used to make the behaviour of synthetic genetic circuits within a single cell or across a cell population more reliable, predictable and robust to perturbations
Implementing control designs in biological hardware introduces technical challenges that require implemented or proposed solutions.
Quoted textsource-backed
The description especially highlights technical challenges that uniquely arise from the need to implement control designs within a new hardware setting, along with implemented or proposed solutions.
The review summarizes applications of control design concepts to problems encountered when building synthetic biomolecular circuits in living cells.
Quoted textsource-backed
This review presents an organized summary of how these control design concepts have been applied to tackle a variety of problems faced when building synthetic biomolecular circuits in living cells.