First-pass extracted concept

ferritin-NCOA4 system

Candidate: concept label1 source documents3 linked claims

Jump to explainers Jump to evidence Jump to sources Jump to claims

Live refresh every 5sNext refresh in 5s

Aliases

ferritin-NCOA4, ferritin-nuclear receptor coactivator 4 (NCOA4)

Extracted Explainers

What the tool is doing

The review describes the ferritin-NCOA4 system as an iron regulatory mechanism that increases intracellular iron levels during iron deficiency. It is specifically tied to ferritinophagy in the abstract.

Source 1DOI PubMed

What problem it solves

It helps explain how stored iron can be mobilized to support intracellular iron homeostasis.

Source 1DOI PubMed

What it does not solve

The abstract does not provide enough detail to treat this as an engineered toolkit component.

Source 1DOI PubMed

Alternatives

The abstract contrasts it with DMT1-transferrin and hepcidin-ferroportin mechanisms.

Source 1DOI PubMed

Evidence Snippets

including hepcidin-ferroportin, divalent metal transporter 1 (DMT1)-transferrin, and ferritin-nuclear receptor coactivator 4 (NCOA4). During iron deficiency, ... ferritin-NCOA4 systems increase intracellular iron levels via ... ferritinophagy

Evidence 1Source 1DOI PubMedprovenance

Supporting Sources

Source 1review2023AntioxidantsDOI PubMed

1 evidence snippet 3 linked claims Claim 1 Claim 2 Claim 3

Linked Claims

Claim 1high level conclusionsupports2023Source 1DOI PubMed

The review concludes that intracellular iron homeostasis is vital for maintaining inflammatory homeostasis.

Claim 2mechanistic summarysupports2023Source 1DOI PubMed

During iron deficiency, DMT1-transferrin and ferritin-NCOA4 systems increase intracellular iron levels via endosomes and ferritinophagy, respectively.

Claim 3mechanistic summarysupports2023Source 1DOI PubMed

The review identifies hepcidin-ferroportin, DMT1-transferrin, and ferritin-NCOA4 as intracellular iron regulatory mechanisms.