First-pass extracted concept

fiberoptic recordings from molecularly defined populations of LH neurons

Candidate: concept label1 source documents4 linked claims

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Extracted Explainers

What the tool is doing

This approach records activity from molecularly defined populations of lateral hypothalamic neurons in awake freely moving mice. In this paper it was used to monitor MCH and orexin/hypocretin network dynamics during wakefulness.

Source 1DOI PubMed

Resources required

The abstract supports the need for molecularly defined LH neuron populations, fiberoptic recording, and awake freely moving mice.

Source 1DOI PubMed

What problem it solves

It addresses the previously unknown dynamics of MCH cells during wakefulness.

Source 1DOI PubMed

Alternatives

The abstract does not explicitly name alternative recording methods.

Source 1DOI PubMed

Evidence Snippets

By fiberoptic recordings from molecularly defined populations of LH neurons in awake freely moving mice

Evidence 1Source 1DOI PubMedprovenance

Supporting Sources

Source 1primary paper2016Nature CommunicationsDOI PubMed

1 evidence snippet 4 linked claims Claim 1 Claim 2 Claim 3

Linked Claims

Claim 1activity modulationsupports2016Source 1DOI PubMed

MCH cell activity is inhibited by stress.

Quoted textsource-backed

is inhibited by stress

Claim 2activity patternsupports2016Source 1DOI PubMed

MCH neurons generate conditional population bursts during wakefulness.

Quoted textsource-backed

By fiberoptic recordings from molecularly defined populations of LH neurons in awake freely moving mice, we show that MCH neurons generate conditional population bursts.

Claim 3behavior correlationsupports2016Source 1DOI PubMed

MCH cell activity correlates with novelty exploration.

Quoted textsource-backed

This MCH cell activity correlates with novelty exploration

Claim 4network relationshipsupports2016Source 1DOI PubMed

MCH cell activity is inversely predicted by orexin/hypocretin cell activity.

Quoted textsource-backed

and is inversely predicted by OH cell activity