This concept refers to fluorescence-based approaches used to dynamically monitor glucose, pyruvate, and lactate in the cancer context.
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fluorescence-based techniques for dynamic monitoring of glucose, pyruvate, and lactate
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Monitoring approaches for glucose, pyruvate, and lactate are highlighted as important for early cancer diagnosis, personalized treatment, and anticancer drug development.
Quoted textsource-backed
We highlight the critical role of these monitoring approaches in advancing early cancer diagnosis, enabling personalized treatment, and accelerating anticancer drug development.
Aerobic glycolysis in cancer leads to extracellular lactate accumulation that acidifies the tumor microenvironment and facilitates tumor invasion and metastasis.
Quoted textsource-backed
This metabolic reprogramming results in extracellular LA accumulation, acidifying the tumor microenvironment (TME) and facilitating tumor invasion and metastasis.
Cancer cells predominantly use aerobic glycolysis, converting glucose to pyruvate and then to lactate.
Quoted textsource-backed
Cancer cells predominantly utilize aerobic glycolysis for energy production, preferentially converting glucose (Glu) to pyruvate (PA) and subsequently to lactate (LA).
The review discusses therapeutic strategies targeting glucose, pyruvate, and lactate and evaluates electrochemical and fluorescence-based techniques for dynamic monitoring of these metabolites.
Quoted textsource-backed
This review comprehensively discussed therapeutic strategies targeting these key metabolites and systematically evaluates electrochemical and fluorescence-based techniques for their dynamic monitoring.