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First-pass extracted concept

FMRP sumoylation

Candidate: concept label1 source documents5 linked claims
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Aliases

sumoylation of FMRP

Extracted Explainers

What the tool is doing

The paper presents FMRP sumoylation as an activity-dependent regulatory mechanism in neurons that affects FMRP behavior in dendritic mRNA granules.

Source 1DOIPubMed

What problem it solves

It provides a mechanistic explanation for how FMRP function can be regulated downstream of neuronal activity.

Source 1DOIPubMed

Evidence Snippets

Here we show that FMRP is a substrate of the small ubiquitin-like modifier (SUMO) pathway in the brain and identify its active SUMO sites.
Evidence 1Source 1DOIPubMedprovenance

Supporting Sources

Linked Claims

Claim 1functional effectsupports2018Source 1DOIPubMed

FMRP sumoylation regulates dendritic spine elimination and maturation.

Quoted textsource-backed
which, in turn, regulates spine elimination and maturation.
Claim 2mechanismsupports2018Source 1DOIPubMed

FMRP is a substrate of the SUMO pathway in the brain.

Quoted textsource-backed
Here we show that FMRP is a substrate of the small ubiquitin-like modifier (SUMO) pathway in the brain and identify its active SUMO sites.
Claim 3mechanismsupports2018Source 1DOIPubMed

Increased FMRP sumoylation controls homomerization of FMRP within dendritic mRNA granules.

Quoted textsource-backed
We then show that this increase in sumoylation controls the homomerization of FMRP within dendritic mRNA granules
Claim 4mechanistic summarysupports2018Source 1DOIPubMed

FMRP sumoylation is a critical activity-dependent regulatory mechanism of FMRP-mediated neuronal function.

Quoted textsource-backed
Altogether, our findings reveal the sumoylation of FMRP as a critical activity-dependent regulatory mechanism of FMRP-mediated neuronal function.
Claim 5regulationsupports2018Source 1DOIPubMed

Activation of metabotropic glutamate receptors promotes FMRP sumoylation.

Quoted textsource-backed
We first demonstrate that FMRP sumoylation is promoted by activation of metabotropic glutamate receptors.