Focused or ultrasonic neuromodulation is presented as a way to excite or control neural activity using ultrasound. The abstract frames it as non-invasive and spatially precise, with potential access to deep brain regions.
First-pass extracted concept
focused ultrasound neuromodulation
Candidate: concept label3 source documents9 linked claims
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Aliases
FUS neuromodulation, ultrasonic neuromodulation
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Evidence Snippets
Additionally, we discuss advancements in FUS neuromodulation, which could complement lesioning by providing temporary or reversible symptom relief.
Ultrasonic neuromodulation has the unique potential to provide non-invasive control of neural activity in deep brain regions with high spatial precision and without chemical or genetic modification.
These efforts have resulted in already-useful neuroscience tools, including high-resolution hemodynamic functional imaging, focused ultrasound neuromodulation, and local drug delivery.
Supporting Sources
Linked Claims
Focused ultrasound neuromodulation could complement lesioning by providing temporary or reversible symptom relief.
Future MRgFUS developments may include frameless technology, staged bilateral procedures, and integration of neuromodulation to enable more precise adaptive therapies.
The mechanistic findings are presented as enabling further development of ultrasonic neuromodulation and sonogenetics for neuroscience research.
Quoted textsource-backed
These findings provide a mechanistic explanation for the effect of ultrasound on neurons to facilitate the further development of ultrasonic neuromodulation and sonogenetics as tools for neuroscience research.
Activation of the implicated mechanosensitive channels causes gradual calcium accumulation that is amplified by calcium-gated and voltage-gated channels to generate burst firing.
Quoted textsource-backed
The activation of these channels results in a gradual build-up of calcium, which is amplified by calcium- and voltage-gated channels, generating a burst firing response.
Focused ultrasound excites primary murine cortical neurons in culture through a primarily mechanical mechanism mediated by specific calcium-selective mechanosensitive ion channels.
Quoted textsource-backed
Here, we show that focused ultrasound excites primary murine cortical neurons in culture through a primarily mechanical mechanism mediated by specific calcium-selective mechanosensitive ion channels.
Cavitation, temperature changes, large-scale deformation, and synaptic transmission are not required for focused-ultrasound excitation of these neurons.
Quoted textsource-backed
Cavitation, temperature changes, large-scale deformation, and synaptic transmission are not required for this excitation to occur.
Pharmacological and genetic inhibition of specific ion channels reduces neuronal responses to ultrasound, whereas overexpression of these channels strengthens ultrasonic stimulation.
Quoted textsource-backed
Pharmacological and genetic inhibition of specific ion channels leads to reduced responses to ultrasound, while over-expressing these channels results in stronger ultrasonic stimulation.
Ultrasound readily permeates the brain and in some cases the skull, with a fundamental resolution on the order of 100 μm and 1 ms.
Quoted textsource-backed
ultrasound readily permeates the brain, and in some cases the skull, and interacts with tissue with a fundamental resolution on the order of 100 μm and 1 ms
Ultrasound-based efforts have produced already-useful neuroscience tools including high-resolution hemodynamic functional imaging, focused ultrasound neuromodulation, and local drug delivery.
Quoted textsource-backed
These efforts have resulted in already-useful neuroscience tools, including high-resolution hemodynamic functional imaging, focused ultrasound neuromodulation, and local drug delivery.