First-pass extracted concept

force-dependent proteolytic switches

Candidate: concept label1 source documents3 linked claims

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Aliases

force-sensing proteolytic switches, ligand-dependent proteolytic switches

Evidence Snippets

The large sequence space of protein domains that can serve as force-sensing proteolytic switches suggests a widespread potential role for force-dependent, ADAM10-mediated proteolysis in other cell contact-dependent signaling mechanisms.

Evidence 1Source 1DOI PubMedprovenance

Supporting Sources

Source 1primary paper2025MEDDOI PubMed

1 evidence snippet 3 linked claims Claim 1 Claim 2 Claim 3

Linked Claims

Claim 1functional substitutionsupports2025Source 1DOI PubMed

Domains from diverse source proteins with varied sequences and predicted structures could functionally substitute for the Notch NRR in vivo.

Claim 2generalizationsupports2025Source 1DOI PubMed

A large sequence space of protein domains can serve as force-sensing proteolytic switches, suggesting that force-dependent ADAM10-mediated proteolysis may be broadly relevant in cell contact-dependent signaling.

Claim 3mechanism dependencesupports2025Source 1DOI PubMed

The substitute domains identified in the screen depended on cleavage by the Drosophila ADAM10 homolog Kuzbanian and on Epsin-mediated ligand endocytosis.