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force-mediated neuromodulation

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In this Account, we categorize force-mediated neuromodulation into two categories: 1) methods where mechanical force is the primary stimulus and 2) methods where mechanical force is generated as a secondary stimulus in response to other modalities.
Evidence 1Source 1DOIPubMedprovenance

Supporting Sources

Linked Claims

Claim 1categorizationsupports2024Source 1DOIPubMed

Force-mediated neuromodulation can be categorized into methods where mechanical force is the primary stimulus and methods where mechanical force is generated secondarily in response to other modalities.

Quoted textsource-backed
In this Account, we categorize force-mediated neuromodulation into two categories: 1) methods where mechanical force is the primary stimulus and 2) methods where mechanical force is generated as a secondary stimulus in response to other modalities.
Claim 2mechanism or modesupports2024Source 1DOIPubMed

Mechanical force can be generated from light or magnetic fields for neuromodulation via mechanosensitive proteins, localizing force at the cellular level and enhancing the precision of the original energy delivery.

Quoted textsource-backed
Conversely, the second form of mechanical force modulation is the generation of mechanical force from other modalities, such as light or magnetic fields, for neuromodulation via mechanosensitive proteins. This approach localizes the mechanical force at the cellular level, enhancing the precision of the original energy delivery.
Claim 3translational potentialsupports2024Source 1DOIPubMed

Direct interaction of mechanical force with tissue has translational potential because it can interface with endogenous mechanosensitive proteins without requiring transgenes.

Quoted textsource-backed
Direct interaction of mechanical force with tissue presents translational potential in its ability to interface with endogenous mechanosensitive proteins without the need for transgenes.