First-pass extracted concept

ΔFosB

Candidate: concept label1 source documents6 linked claims

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Aliases

DeltaFosB

Evidence Snippets

The transcription factor ΔFosB and the brain-enriched calcium/calmodulin-dependent protein kinase II (CaMKIIα) are induced in the nucleus accumbens (NAc) by chronic exposure to cocaine.

Evidence 1Source 1DOI PubMedprovenance

Supporting Sources

Source 1primary paper2013Journal of NeuroscienceDOI PubMed

1 evidence snippet 6 linked claims Claim 1 Claim 2 Claim 3

Linked Claims

Claim 1dependencysupports2013Source 1DOI PubMed

CaMKII is required for cocaine-mediated accumulation of ΔFosB in rat nucleus accumbens.

Claim 2dependencysupports2013Source 1DOI PubMed

ΔFosB-driven dendritic spine induction on nucleus accumbens medium spiny neurons and increased behavioral responsiveness to cocaine are CaMKII dependent.

Claim 3human observationsupports2013Source 1DOI PubMed

ΔFosB and CaMKII are induced in the nucleus accumbens of human cocaine addicts.

Claim 4mechanismsupports2013Source 1DOI PubMed

CaMKIIα phosphorylates ΔFosB at Ser27, a protein-stabilizing site.

Claim 5mechanismsupports2013Source 1DOI PubMed

ΔFosB and CaMKII form a cell-type- and brain-region-specific positive feedforward loop that regulates reward circuitry responses to chronic cocaine.

Claim 6necessity sufficiencysupports2013Source 1DOI PubMed

ΔFosB is necessary and sufficient for cocaine induction of CaMKIIα gene expression in vivo, selectively in D1-type medium spiny neurons of the nucleus accumbens shell.