First-pass extracted concept

free radical theory of aging

Candidate: concept label2 source documents1 linked claims

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Evidence Snippets

Anchor paper: Denham Harman’s 1993 article "Free radicals and aging" ... sits within the long-running free radical theory of aging literature.

Evidence 1Source 1DOIprovenance

We argue that this damage ... is a major contributor to aging and to degenerative diseases of aging.

Evidence 2Source 2DOI PubMedprovenance

Supporting Sources

Source 1primary paper1993Free Radical Biology and MedicineDOI

1 evidence snippet 0 linked claims

Source 2review1993Proceedings of the National Academy of SciencesDOI PubMed

1 evidence snippet 1 linked claim Claim 1

Linked Claims

Claim 1disease mechanism summarysupports1993Source 2DOI PubMed

The review argues that oxidant-induced macromolecular damage is a major contributor to aging and degenerative diseases of aging, including cancer, cardiovascular disease, immune-system decline, brain dysfunction, and cataracts.