First-pass extracted concept

fusion regulatory protein-1

Candidate: concept label1 source documents7 linked claims

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Aliases

4F2/CD98 heavy chain, FRP-1

Extracted Explainers

What the tool is doing

FRP-1 is described as a cell-fusion regulatory system composed of disulfide-linked heavy and light chains. The heavy chain is stated to be identical to 4F2/CD98 heavy chain and is described as multifunctional.

Source 1DOI PubMed

Resources required

The abstract states that FRP-1 includes a heavy chain associated with light chains, and that the light chains require association with the heavy chain to exhibit amino acid transport activity.

Source 1DOI PubMed

What problem it solves

The source presents FRP-1 as participating in regulation of cell fusion, amino acid transport, integrin-related functions, and T-cell activation.

Source 1DOI PubMed

What it does not solve

The abstract does not define a discrete engineered use-case, protocol, or intervention that FRP-1 alone solves.

Source 1DOI PubMed

Alternatives

The abstract contrasts FRP-1 with FRP-2, which it identifies as integrin alpha3 subunit.

Source 1DOI PubMed

Evidence Snippets

Two molecules that regulate cell fusion have been identified and designated fusion regulatory protein-1 (FRP-1) and FRP-2. FRP-1 is a complex composed of a glycosylated heavy chain and a nonglycosylated light chain that are disulfide linked. FRP-1 heavy chain is identical to 4F2/CD98 heavy chain, whereas FRP-2 is identical to integrin alpha3 subunit.

Evidence 1Source 1DOI PubMedprovenance

Supporting Sources

Source 1primary paper2000Critical Reviews in ImmunologyDOI PubMed

1 evidence snippet 7 linked claims Claim 1 Claim 2 Claim 3

Linked Claims

Claim 1biological involvementsupports2000Source 1DOI PubMed

The FRP-1 system is involved in virus-mediated cell fusion and multinucleated giant cell formation of blood monocytes.

Claim 2functional rolesupports2000Source 1DOI PubMed

The FRP-1 heavy chain is a multifunctional molecule that acts as a fusion regulator, amino acid transporter, integrin regulator, comitogenic factor, Na+-Ca2+ exchanger, and oncogenic protein.

Claim 3identitysupports2000Source 1DOI PubMed

FRP-1 heavy chain is identical to 4F2/CD98 heavy chain.

Claim 4immune regulationsupports2000Source 1DOI PubMed

Novel pathways for monocyte-dependent regulation of T-cell activation are mediated by the FRP-1 system.

Claim 5mechanistic requirementsupports2000Source 1DOI PubMed

FRP-1 light chains require association with the heavy chain to exhibit amino acid transport activity.

Claim 6perturbation effectsupports2000Source 1DOI PubMed

Monoclonal antibodies against human FRP-1 heavy chain induce polykaryocytes that have properties as osteoclasts.

Claim 7structure functionsupports2000Source 1DOI PubMed

FRP-1 is a complex of a glycosylated heavy chain and a nonglycosylated light chain that are disulfide linked.