First-pass extracted concept

gamma oscillations

Candidate: concept label3 source documents9 linked claims
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Evidence Snippets

Gamma oscillation is the synchronization with a frequency of 30-90 Hz of neural oscillations, which are rhythmic electric processes of neuron groups in the brain.
Evidence 1Source 1DOIPubMedprovenance
Scientists are gradually moving away from the simple assumption, as proposed in the original amyloid hypothesis, to new theories of pathogenesis, including gamma oscillations, prion transmission, cerebral vasoconstriction, growth hormone secretagogue receptor 1α (GHSR1α)-mediated mechanism, and infection.
Evidence 2Source 2DOIPubMedprovenance
Activity in the theta, beta, and gamma bands is related to communication between PFC and different brain areas.
Evidence 3Source 3DOIPubMedprovenance

Supporting Sources

Linked Claims

Claim 1disease association summarysupports2022Source 1DOIPubMed

Abnormal gamma oscillations have been linked to Alzheimer's disease, Parkinson's disease, and schizophrenia.

Claim 2functional role summarysupports2022Source 1DOIPubMed

Gamma oscillations control connectivity between different brain regions and are important for perception, movement, memory, and emotion.

Claim 3mechanistic summarysupports2022Source 1DOIPubMed

Brain inflammation, oxidative stress, and metabolic imbalances can disrupt the interneuron network required for gamma oscillations.

Claim 4mechanistic summarysupports2022Source 1DOIPubMed

Inhibitory interneuron networks are necessary for the production of gamma oscillations.

Claim 5field shift summarysupports2020Source 2DOIPubMed

The review states that Alzheimer's disease pathogenesis research is moving beyond the original amyloid hypothesis toward additional mechanisms including gamma oscillations, prion transmission, cerebral vasoconstriction, GHSR1α-mediated mechanisms, and infection.

Quoted textsource-backed
Scientists are gradually moving away from the simple assumption, as proposed in the original amyloid hypothesis, to new theories of pathogenesis, including gamma oscillations, prion transmission, cerebral vasoconstriction, growth hormone secretagogue receptor 1α (GHSR1α)-mediated mechanism, and infection.
Claim 6review scope summarysupports2020Source 2DOIPubMed

The review states that amyloid and tau are the most recognized Alzheimer's disease hypotheses.

Quoted textsource-backed
the most recognized hypotheses are the amyloid and tau hypotheses
Claim 7therapeutic landscape summarysupports2020Source 2DOIPubMed

The review states that almost all clinical trials targeting amyloid and tau mechanisms have not identified effective methods to treat Alzheimer's disease.

Quoted textsource-backed
However, almost all clinical trials targeting these mechanisms have not identified any effective methods to treat AD.
Claim 8mechanistic summarysupports2011Source 3DOIPubMed

Gamma and beta oscillations mediate bottom-up and top-down interactions between prefrontal cortex and visual cortices in attention-related processing.

Quoted textsource-backed
While gamma/beta oscillations mediate bottom-up and top-down interactions between PFC and visual cortices, related to attention
Claim 9mechanistic summarysupports2011Source 3DOIPubMed

Theta, beta, and gamma band activity is related to communication between prefrontal cortex and other brain areas.

Quoted textsource-backed
Activity in the theta, beta, and gamma bands is related to communication between PFC and different brain areas.