Gas vesicles are described as genetically encoded ultrasound contrast agents. In this paper they are the expressed structures underlying acoustic reporter function.
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gas vesicles
Candidate: concept label7 source documents12 linked claims
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GVs
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constructing ultrasound-visible engineered bacteria expressing gas vesicles on the genome
the gas vesicles (GVs) expressed in GVs-E. coli can effectively synergize to FUAS through their cavitation effect and perform USI
Gas vesicles (GVs) are genetically encodable, air-filled protein nanostructures
Recent advances in acoustic contrast agents, such as microbubbles and gas vesicles, have improved the mechanical effects of ultrasound on cells
A promising new field of genetically encoded ultrasound contrast agents in the form of gas vesicles has recently emerged.
Gas vesicles (GVs) based on acoustic reporter genes have emerged as potent contrast agents for cellular and molecular ultrasound imaging.
without overexpressing calcium channels or gas vesicles
Supporting Sources
Linked Claims
Recent advances in acoustic contrast agents including microbubbles and gas vesicles have improved the mechanical effects of ultrasound on cells and extended its application to various biological systems.
Gas vesicles expressed in GVs-E. coli synergize with FUAS through a cavitation effect and enable ultrasound imaging.
Sequential expression in which assembly factors are initiated before GvpA2 restores growth without compromising gas vesicle production.
Gas vesicle induction causes a reproducible drop in cell density and viability 8-16 hours after induction.
Heterologous gas vesicle expression in Escherichia coli is hampered by complex multicomponent assembly that provokes proteotoxic stress and impaired growth.
The interval between inductions tunes both gas vesicle yield and cellular stress.
Gas vesicles based on acoustic reporter genes are potent contrast agents for cellular and molecular ultrasound imaging.
The engineered sonogenetic system enables acoustic control of a therapeutic cellular device in deep tissue without overexpressing calcium channels or gas vesicles.
Quoted textsource-backed
engineers a therapeutic cellular device responsive to acoustic stimulation in deep tissue without overexpressing calcium channels or gas vesicles
HxAM imaging enhances in vivo imaging performance by over 10 dB.
HxAM imaging surpasses traditional xAM in isolating the nonlinear acoustic signature of gas vesicles.
Cells expressing gas vesicles exhibited greater ultrasound signal-to-noise ratio than controls.
Quoted textsource-backed
Successful gas vesicle expression was optically and ultrasonically verified, with cells expressing gas vesicles exhibiting an 80% greater signal-to-noise ratio compared to negative controls and a 500% greater signal-to-noise ratio compared to wild-type HEK293T cells.
HxAM imaging improves detection of GV-producing cells up to threefold in vitro.