Therefore, modern approaches to metabolic engineering should embrace genetic circuits that incorporate dynamic regulatory mechanisms.
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genetic circuits with dynamic regulatory mechanisms
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Incorporating dynamic control mechanisms can make synthetic pathways more robust to environmental fluctuations during scale-up and more precisely regulated in therapeutic contexts such as responsive drug delivery.
Traditional metabolic engineering has often emphasized direct construction of synthetic metabolic pathways while underemphasizing regulatory control.
Dynamic regulation of synthetic metabolic pathways improves the reliability, robustness, scalability, and stability of cell factories.