This review investigates multiple genetic mouse models of ASD to explore whether abnormalities in striatal circuits constitute a common pathophysiological mechanism in the development of autism-related behaviors.
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genetic mouse models of ASD
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Across heterogeneous genetic ASD models, numerous models show altered striatal circuit structure and function together with abnormal repetitive, social, and decision-making behaviors.
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Despite the heterogeneity of genetic insult investigated, numerous genetic ASD models display alterations in the structure and function of striatal circuits, as well as abnormal behaviors including repetitive grooming, stereotypic motor routines, deficits in social interaction and decision-making.
The review evaluates striatal circuit abnormalities as a potential common pathophysiological mechanism underlying autism-related behaviors across multiple genetic mouse models.
Quoted textsource-backed
This review investigates multiple genetic mouse models of ASD to explore whether abnormalities in striatal circuits constitute a common pathophysiological mechanism in the development of autism-related behaviors.
Comparative rodent analysis may help use genetic association data to identify canonical neural circuits contributing to discrete ASD symptom domains and suggest treatment routes.
Quoted textsource-backed
Comparative analysis in rodents provides a unique opportunity to leverage growing genetic association data to reveal canonical neural circuits whose dysfunction directly contributes to discrete aspects of ASD symptomatology. The description of such circuits could provide both organizing principles for understanding the complex genetic etiology of ASD as well as novel treatment routes.