This review describes genetic strategies used to target specific cortical and hippocampal GABAergic interneuron subtypes.
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genetic strategies for targeting specific GABAergic interneuron subtypes
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These methods have facilitated understanding of how interneuron subtypes regulate forebrain circuitry through cell type- and compartment-specific inhibition and suggest paths toward therapeutic interventions for neurocognitive disorders.
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Collectively, these methods have greatly facilitated our understanding of how IN subtypes regulate forebrain circuitry via cell type and compartment-specific inhibition and thus have illuminated a path toward potential therapeutic interventions for a variety of neurocognitive disorders.
The paper summarizes genetic strategies used to target specific cortical and hippocampal GABAergic interneuron subtypes and discusses technical considerations for each approach.
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we outline the emerging picture of cortical and hippocampal IN speciation as defined by transcriptomics and developmental origin and summarize the genetic strategies that have been utilized to target specific IN subtypes, along with the technical considerations inherent to each approach
Genetic tools together with single-cell transcriptomic data have begun to reveal the molecular basis of mammalian forebrain GABAergic interneuron diversity.
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Over the last few decades, the development of a palette of genetic tools along with the generation of single-cell transcriptomic data has begun to reveal the molecular basis of IN diversity