First-pass extracted concept

genetically based tools for mapping and manipulating neural circuits

Candidate: concept label1 source documents3 linked claims

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Evidence Snippets

The availability of new, genetically based tools for mapping and manipulating neural circuits at the level of specific, genetically defined neuronal subtypes provides an opportunity to investigate the functional organization of aggression circuitry with cellular resolution.

Evidence 1Source 1DOI PubMedprovenance

Supporting Sources

Source 1review2011Biological PsychiatryDOI PubMed

1 evidence snippet 3 linked claims Claim 1 Claim 2 Claim 3

Linked Claims

Claim 1circuit localizationsupports2011Source 1DOI PubMed

Neurons necessary and sufficient for inter-male aggression are located within the ventrolateral subdivision of the ventromedial hypothalamic nucleus.

Claim 2method comparisonsupports2011Source 1DOI PubMed

Genetically based tools for mapping and manipulating neural circuits provide cellular-resolution access to specific neuronal subtypes, whereas classical electrical stimulation and electrolytic lesion have limited resolution for studying aggression circuitry.

Claim 3population overlapsupports2011Source 1DOI PubMed

Aggression-related neurons in VMHvl are intermingled with neurons activated during male-female mating, with approximately 20% overlap between the populations.