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genetically encoded activity sensors

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genetically encoded activity sensors have brought the goal of optical detection of single action potentials in vivo within reach
Evidence 1Source 1DOIPubMedprovenance

Supporting Sources

Linked Claims

Claim 1capabilitysupports2015Source 1DOIPubMed

Combining activity sensors, optogenetic actuators, and advanced microscopy enables all-optical readout and manipulation of neural circuit activity with single-spike and single-neuron precision.

Quoted textsource-backed
These revolutions have now been combined, together with advanced microscopies, to allow "all-optical" readout and manipulation of activity in neural circuits with single-spike and single-neuron precision.
Claim 2capabilitysupports2015Source 1DOIPubMed

Genetically encoded activity sensors have brought optical detection of single action potentials in vivo within reach.

Quoted textsource-backed
genetically encoded activity sensors have brought the goal of optical detection of single action potentials in vivo within reach
Claim 3capabilitysupports2015Source 1DOIPubMed

Sensors and optical strategies can be combined with sufficient sensitivity and low enough cross talk to enable single-action-potential sensitivity and precision for both readout and manipulation in the intact brain.

Quoted textsource-backed
It has recently become possible to combine sensors and optical strategies that are sufficiently sensitive and cross talk free to enable single-action-potential sensitivity and precision for both readout and manipulation in the intact brain.
Claim 4requirementsupports2015Source 1DOIPubMed

All-optical interrogation requires coexpression of genetically encoded activity sensors and optogenetic probes in the same neurons together with the ability to target and record light from selected neurons.

Quoted textsource-backed
Harnessing the power of light in the all-optical approach requires coexpression of genetically encoded activity sensors and optogenetic probes in the same neurons, as well as the ability to simultaneously target and record the light from the selected neurons.