This review covers genetically encoded approaches for inhibiting neuronal activity. These tools are used to reversibly silence selected neuronal populations.
First-pass extracted concept
genetically encoded neuronal silencing tools
Candidate: concept label1 source documents5 linked claims
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What the tool is doing
What problem it solves
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Evidence Snippets
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Linked Claims
The utility of neuronal silencing tools depends on the particular experimental application.
Quoted textsource-backed
provide an in-depth analysis of their mechanism of action and utility for particular experimental applications
Design and interpretation of neuronal silencing experiments present unique technical and conceptual challenges.
Quoted textsource-backed
the design and interpretation of neuronal silencing experiments present unique challenges, both technically and conceptually
The number of genetically encoded tools for inhibition of neuronal activity has expanded substantially.
Quoted textsource-backed
the number of genetically encoded tools used for inhibition of neuronal activity has vastly expanded
Neuronal silencing strategies vary widely in mechanism of action and in spatial and temporal scales.
Quoted textsource-backed
Silencing strategies vary widely in their mechanism of action and in their spatial and temporal scales.
Reversible neuronal silencing is a powerful approach for isolating the roles of specific neuronal populations in circuit dynamics and behavior.
Quoted textsource-backed
Reversible silencing of neuronal activity is a powerful approach for isolating the roles of specific neuronal populations in circuit dynamics and behavior.