Scientists are gradually moving away from the simple assumption, as proposed in the original amyloid hypothesis, to new theories of pathogenesis, including gamma oscillations, prion transmission, cerebral vasoconstriction, growth hormone secretagogue receptor 1α (GHSR1α)-mediated mechanism, and infection.
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GHSR1α-mediated mechanism
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growth hormone secretagogue receptor 1α (GHSR1α)-mediated mechanism
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The review states that Alzheimer's disease pathogenesis research is moving beyond the original amyloid hypothesis toward additional mechanisms including gamma oscillations, prion transmission, cerebral vasoconstriction, GHSR1α-mediated mechanisms, and infection.
Quoted textsource-backed
Scientists are gradually moving away from the simple assumption, as proposed in the original amyloid hypothesis, to new theories of pathogenesis, including gamma oscillations, prion transmission, cerebral vasoconstriction, growth hormone secretagogue receptor 1α (GHSR1α)-mediated mechanism, and infection.
The review states that amyloid and tau are the most recognized Alzheimer's disease hypotheses.
Quoted textsource-backed
the most recognized hypotheses are the amyloid and tau hypotheses
The review states that almost all clinical trials targeting amyloid and tau mechanisms have not identified effective methods to treat Alzheimer's disease.
Quoted textsource-backed
However, almost all clinical trials targeting these mechanisms have not identified any effective methods to treat AD.