glioblastoma multiforme

Silica-, metal-, and carbon-based nanomaterials enable multimodal applications including tumor imaging, localized hyperthermia, and selective induction of cancer cell death in the glioblastoma context.

Functionalization with targeting ligands or surface modifications further enhances tumor penetration and therapeutic efficacy of inorganic nanoparticle platforms for glioblastoma.

In glioblastoma, treatment failure is largely driven by the blood-brain barrier because it restricts delivery of most conventional therapeutics and shields invasive tumor regions from systemic drugs.

Recent inorganic nanoparticles are designed to cross the blood-brain barrier and target glioblastoma.

Despite promising preclinical results, clinical translation of inorganic nanoparticle strategies for glioblastoma requires careful optimization of nanoparticle properties to minimize toxicity and immune clearance.