The review frames the GBM tumor microenvironment as the heterogeneous cellular and chemical environment surrounding and interacting with glioblastoma cells.
First-pass extracted concept
glioblastoma tumor microenvironment
Candidate: concept label1 source documents5 linked claims
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Aliases
GBM TME, GBM tumor microenvironment
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Glioblastoma cells communicate with the tumor microenvironment through direct cell-surface interactions and indirect apocrine or paracrine signaling via cytokines, growth factors, and extracellular vehicles.
Emerging evidence suggests that glioblastoma cells reprogram and hijack microenvironmental elements to promote proliferation, invasion, migration, survival, and treatment resistance.
The glioblastoma tumor microenvironment is dynamically shaped by cellular composition, cell-cell contact, metabolic products, pH, and oxygen levels.
The glioblastoma tumor microenvironment is highly heterogeneous and complex, comprising cancer cells together with resident brain cells, immune cells, and cells transiting through the tumor.
The review covers models for studying the glioblastoma tumor microenvironment and current studies targeting tumor microenvironment components for therapeutic purposes.