The review defines gliotransmission as active information transfer from glia to neurons. It is presented as a potentially important contributor to information processing in neural circuits.
First-pass extracted concept
gliotransmission
Candidate: concept label2 source documents7 linked claims
Live refresh every 5sNext refresh in 5s
Extracted Explainers
What the tool is doing
What problem it solves
What it does not solve
Evidence Snippets
Astrocytes... have emerged as active participants in synaptic communication through Ca2+-dependent molecular signalling often referred to as gliotransmission.
Gliotransmission (active information transfer from glia to neurons) has probably the widest implications on our understanding of how the brain works.
Supporting Sources
Linked Claims
Astrocytes actively participate in synaptic communication through Ca2+-dependent molecular signalling referred to as gliotransmission.
Quoted textsource-backed
Astrocytes, once considered passive support cells, have emerged as active participants in synaptic communication through Ca2+-dependent molecular signalling often referred to as gliotransmission.
Methodologically advanced studies have produced negative evidence that contradicts positive gliotransmission reports and triggered debate about the existence and properties of gliotransmission.
Quoted textsource-backed
In striking contradiction, methodologically advanced studies by a few laboratories produced "negative evidence," triggering a heated debate on the actual existence and properties of gliotransmission.
Multiple laboratories have reported modulatory chemical signaling from astrocytes to neurons on timescales of hundreds of milliseconds to several minutes.
Quoted textsource-backed
"Positive evidence" for this stems from work of multiple laboratories reporting many examples of modulatory chemical signaling from astrocytes to neurons in the timeframe of hundreds of milliseconds to several minutes.
Reported gliotransmission mechanisms include Ca2+-dependent vesicular transmitter release, and associated synaptic regulatory effects are abolished by preventing astrocytic Ca2+ elevations or blocking astrocyte-selective exocytosis.
Quoted textsource-backed
This signaling involves, but is not limited to, Ca2+-dependent vesicular transmitter release, and results in a variety of regulatory effects at synapses in many circuits that are abolished by preventing Ca2+ elevations or blocking exocytosis selectively in astrocytes.
Correct study and understanding of gliotransmission require more sophisticated tools and finer experiments than have been used to date.
Quoted textsource-backed
whose correct study and understanding require more sophisticated tools and finer scientific experiments than done until today
Gliotransmission is likely more complex than originally thought and may consist of multiple forms and signaling processes.
Quoted textsource-backed
we argue that gliotransmission is a more complex phenomenon than originally thought, possibly consisting of multiple forms and signaling processes
The review argues that several assumptions used to dismiss positive gliotransmission evidence are likely wrong and oversimplistic.
Quoted textsource-backed
We here discuss how the above assumptions are likely wrong and oversimplistic.